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Bone loss during the fat loss period (fat loss model in obese rats) Experimental Design: Animals: Obese SD rats induced by high-fat diet were randomly divided into an obesity control group, a simple weight loss group (30% calorie restriction), and a weight loss+AOD 9604 group (500 g/kg/day)

Mitochondria are essential organelles, whose dysfunction is central to major diseases 13,14 , as they are the center for aerobic ATP generation from oxidative phosphorylation (Oxphos) in the electron transport chain (ETC)

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