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Lactate can induce lactylation at the lysine 72 (K72) site of MOESIN, thereby potentiating the signaling interface between TGF- and its downstream SMAD3 through TGF- receptor I, thereby amplifying Treg development within the TME (123)

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The second concept is the parallel concept, which proposes that migraine aura and migraine headache are separate events occurring in close temporal relation and in response to a shared initiating factor [27, 28]

SUBSTITUTE SHEETS (RULE 26) The term "amino acid" as used herein refers to an organic compound comprising at least one amino group and at least one acidic group

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