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PMID 38665151

doi: 10.1016/j.phymed.2021.153544 101

Green Chef

When approaching the isoelectric point (IEP) of the protein at about pH 4.5 (and below), the resulting CGN-protein structure with increased crosslinkages is so strong that the complex will precipitate

The FDA's concerns about immunogenicity at certain injection routes and inconsistent pharmaceutical-grade characterization across suppliers are legitimate issues not invented ones