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Hydrogen peroxide participates in autocatalytic covalent heme binding to the apoprotein of TPO molecule, thereby stabilizing the activity of the enzyme [141]

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Following the ancestral preparation used by the Amazonian Achuar groups, after boiling the guayusa leaves for 1 h, a concentration of around 3% caffeine is obtained, but when using leaves from wild specimens the concentration of this alkaloid can reach up to 7.57% [11,14]

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To resolve this, researchers developed the Glutamic acid-Valine-Citrulline (EVCit) linker by adding an acidic amino acid at the N-terminus (Figure 6b) [5]

Licorice Root also contains a flavonoid