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Trends Pharmacol Sci 44(12):949962

doi: 10.5468/ogs.2019.62.4.242 69 JiHZhangZChenCXuWLiuTDongYet al

Trinchieri A

Ettinger B, Pak CY, Citron JT, Thomas C, Adams-Huet B, Vangessel A

Both 4-HNE and MDA are extensively studied markers of lipid peroxidation, with MDA recognized as a mutagenic product of lipid peroxidation and 4-HNE recognized as the most toxic product of lipid oxidation (104), worsening the damage resulting from oxidative stress (105, 106)

AMPK regulates cellular energy homeostasis and works by: Increasing glucose uptake and improving insulin sensitivity: This effect is most notable in skeletal muscle [2]