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Perioperative implications were evaluated with emphasis on orthopaedic surgical risk domains relevant to total joint arthroplasty (TJA), including wound complications, hematoma formation, immune modulation, infection susceptibility, heterotopic ossification, and implant fixation considerations

132 Furthermore, comprehensive analyses have identified exosomal involvement in multiple T2DM-related pathways, with animal studies systematically evaluating their therapeutic efficacy in DPN management (see Table 3)

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