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While more severe forms are not all that common, some research estimates that MCAS could affect up to 17% of the population on a spectrum from very mild to debilitating symptoms.[ref] Others include very mild symptoms such as allergic rhinitis in the mast cell activation spectrum, which includes up to 30% of the population.[ref]
Nwaneri C, Copper H, Bowen-Jones D
Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver
the lone MOTS-c human trial tested a different molecule
These early changes are subtle and easily attributed to placebo effect
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