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Potential side effects include gastrointestinal discomfort, such as bloating or diarrhea
When bound, the liver and other, less influential organs are instructed to produce IGF-1
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Moreover, downregulation of IGF-1R, obtained by antisense strategies, has been reported to elicit a host response leading to eradication of surviving malignant cells in vivo (Resnicoff et al, 1996)
Some peptides are not FDA-approved for anti-aging, weight loss, or wellness indications
IGF1R is a receptor tyrosine kinase, meaning ligand binding triggers autophosphorylation and downstream signaling cascade activation
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