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The peptide's effects on circadian regulation and sleep may provide particular benefit during perimenopause when these systems become disrupted

Its also not the most effective use of limited health budgets

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In marked contrast, PF 06882961 was active in all assays (30-100-fold lower potency than GLP-1), displaying similar maximal internalisation to GLP-1, but only partial agonism in pERK1/2, calcium mobilisation and -arrestin recruitment ( Figures 1B-1G & S1 )