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In PD, collagen-dense plaques with diffusion-limited architecture restrict uniform penetration and retention of biologic agents

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Administering this peptide by injection or nasal spray is critical to ensuring high bioavailability, as DSIP cannot cross the epithelium-mimicking Caco-2 cell layer system

This may indicate inadequate response to the medication, requiring dose adjustment, evaluation of administration technique, or consideration of alternative or adjunctive therapies

Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity