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That tracks with previous research showing that many patients regain weight quickly after stopping GLP-1s, once the drugs appetite-suppressing and fullness-promoting effects wear off

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Studies have shown that TREM2 (triggering receptor expressed on myeloid cells 2), a surface receptor on microglia, plays a pivotal role in regulating their polarization status

doi: 10.2337/db25-0096 65 AllamMMEl-ZawawyHT

In his experience, someone who has multiple medications for conditions like blood pressure, depression, and chronic pain is likely to develop issues with constipation especially if they add a GLP-1, he says

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