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siRNA-mediated knockdown of Nrf2 and CYPOR For transfection of HepG2 in (an individual well) of a 6-well plate (5 10 5 cells/well), solution A, consisting of 4 l Lipofectamine (Life Technologies) and 150 l Opti-MEM (Life Technologies) were mixed

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Various drugs, including astaxanthin and biochanin A, alleviate cartilage degeneration in osteoarthritis by inhibiting ferroptosis (45,46)