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Glutathione exists in reduced (GSH) and oxidized (GSSG) forms, with most cellular compartments maintaining a highly reducing GSSG:GSH ratio ranging from 1:10 to 1:100

doi: 10.1016/j.neuint.2021.105182 480 ShenYYangRZhaoJChenMChenSJiBet al

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In terms of comparisons among immune checkpoint inhibitors for acral melanoma, a systematic review reported the better outcome of the combination therapy of anti-CTLA4 and anti-PD-1 agents (objective response rate: 42.9%) compared with that of each monotherapy [111]