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This dual mechanism has prompted interest in whether these medications might help individuals struggling with binge eating disorder (BED) or recurrent binge eating episodes

The SUSTAIN-6 Trial (Once-Weekly Semaglutide) The Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) consisted of 3297 people living with T2DM, 83% with established cardiovascular disease, receiving once-weekly semaglutide (0.5 and 1.0 mg) or placebo

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The only GLS inhibitor to have entered clinical trials is commonly referred to as CB-839 or commercially as Telaglenastat

Side Effects and Safety Profile Like other incretin-based therapies, the most commonly reported side effects are gastrointestinal, including: Nausea Vomiting Diarrhea Reduced appetite Full safety data is still being evaluated in ongoing Phase 3 clinical trials