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DPP4 in diabetes

Biochim Biophys Acta (2017) 1863(5):107889

Weight trajectories stabilized after 12 months, with only small variations in the distribution of weight outcomes through year two

Leptin is produced not only in the adipose tissue but also in the gastrointestinal tract, particularly in the stomach, where it has been shown to protect the gastric mucosa against various topical irritants and ulcerogens, acting, at least in part, via enhancement of mucosal blood flow due to increased production of nitric oxide (NO) caused by upregulation of NO synthase as well as the activation of brain-gut axis pathways (48, 49)

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These results are consistent with numerous findings in various studies in other tissues