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Increased serum osteopontin levels in autistic children: relation to the disease severity

The rationale is that smaller, more frequent doses may produce smoother drug levels with fewer peak-related side effects

doi:10.1002/ptr.3502 Rodrguez-Ramiro I, Ramos S, Bravo L, Goya L, Martn M (2011) Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway

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Given that the mevalonate pathway is responsible for the production of both metabolites, and this pathway is subject to intricate feedback regulations by sterols, it is not unreasonable to hypothesize that cholesterol metabolism could be one type of such metabolic stress