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The absence of trial data on the combination means any interaction would have to be inferred from theory rather than evidence

Proceedings of the National Academy of Sciences, 113 (27), 7650-7654

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However, the relevance of these findings to humans are unclear since the long-isoform receptor of leptin is present in fetal pituitaries and in pituitary tumors developed during postnatal life, but absent in pituitaries obtained from normal subjects postnatally [36]