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These side effects are dose-dependent and tend to be most pronounced during dose escalation

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It contains valerianic acid, sesquiterpenes, and iridoid glycosides, which potentiate GABAergic neurotransmission, providing anticonvulsant and sedative effects

Transient, mostly mild-to-moderate gastrointestinal events were the most frequently reported adverse events, occurring primarily during dose escalation

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Conclusion: There is a need to create awareness of acanthosis nigricans because many dont take this thickening or darkening serious