doi: 10.1016/j.yrtph.2020.104665
Apart from the potential effects on lean mass gain and fat loss , the literature suggests that GHRH analogs like sermorelin may theoretically trigger improvements in the following peripheral areas of health: Cognitive function Growth hormone is believed to interact with central nervous system receptors associated with learning and memory, and decreased IGF-1 levels have been linked to cognitive decline in the elderly.13 14 So it follows that stimulating GHRH with sermorelin could improve cognitive function
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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)
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