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Who Should Be Careful Although the ColonBroom formulation is mostly safe, there are some situations where caution is needed: Pregnancy and Breastfeeding Berberine is generally not recommended during pregnancy or while breastfeeding

In healthy and type-2 diabetic humans, it has been consistently demonstrated, that GIP, even in rather high (supraphysiological) doses, does not lead to GLP-1 secretion [[328], [329], [330]]

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