Nausea Vomiting Heartburn Abdominal discomfort Diarrhea Constipation Bloating Indigestion Burping Fatigue Headache Mild redness, itching, or soreness at the injection site Less Common but Important Risks Gallbladder disease or gallstones requiring removal of gallbladder Delayed stomach emptying (gastroparesis) Pancreatitis Kidney Considerations Severe dehydration related to persistent vomiting or diarrhea may increase the risk of acute kidney injury
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Results demonstrated that tirzepatide achieved MASH resolution without worsening fibrosis in approximately 44% (5 mg), 56% (10 mg), and 62% (15 mg) of participants , compared to about 10% in the placebo group