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For instance, in the SURPASS trials 1 , patients taking tirzepatide experienced up to 20.2% body weight reduction , compared to around 13.7% for semaglutide

The cardiovascular benefits of semaglutide also help with several mechanisms beyond weight loss, including reductions in blood pressure, blood lipids, and inflammation, as well as direct effects on the heart muscle and blood vessels

Pediatric trials are quietly underway to support prescribing GLP-1 medications for obesity in children younger than 12, despite concerns about their long-term effects on developing bodies

Brad RittiLocal Guide I started a year ago, I was able to loose 60 pounds in a 4 months period

The SELECT trial is a major breakthrough, says Yale Medicine cardiologist Harlan Krumholz, MD, SM, explaining that while semaglutide [given as Ozempic] was already known to lower the risk of heart disease in people with diabetes, the SELECT trial was the first to show that Wegovy, which contains a higher dose of semaglutide, also lowers that risk even in people who dont have diabetes

Mean increases in resting heart rate have been observed in randomized clinical trials of semaglutide and are documented in FDA prescribing information