One of the most common questions GPs now hear is whether switching from Wegovy to Mounjaro makes sense
The off-label approach: Spacing doses every 14 days Healthcare providers may recommend an alternative strategy for some patients in which the same semaglutide dose is administered every 14 days instead of every 7 days
Several hypothalamic nuclei, including the arcuate (ARC), ventromedial (VMH), dorsomedial (DMH), paraventricular (PVH), the lateral hypothalamic area (LHA) regions and the master circadian clock SCN, express GHSR and play major roles in mediating ghrelin-induced effects on energy metabolism [51, 69, 70]
While this finding has not been confirmed in humans during extensive clinical trials and post-marketing surveillance, the FDA requires a boxed warning on GLP-1 receptor agonist labels regarding this potential risk
Age does not appear to meaningfully alter semaglutide pharmacokinetics, and no dose adjustments are recommended for elderly patients
In practice, this means people often feel full more quickly, have fewer cravings, and find it easier to adjust their eating habits in support of their weight loss goals
