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2019 Jun Alejandro A Nava-Ocampo, Aleksandra Pastrak, Tony Cruz, Gideon Koren

Trichoplusia ni cell pellets were suspended in 30 mM HEPES (pH 7.4), 50 mM NaCl, 5 mM CaCl 2 , 2 mM MgCl 2 supplemented with protease inhibitors (REF118361 45001, Roche) and benzonase (Merk Millipore)

The pathogenesis of BO is not well-understood although genetic and environmental factors play significant roles

Start: 200 mcg once daily Increase: Add ~200 mcg every 2 weeks as tolerated Target Range: 400600 mcg once daily Frequency: Once daily Cycle Length: Typically 812 weeks Timing: Any consistent daily time

The MHRA has not issued peptide-specific guidance between 2024 and 2026 that would change this position [unverified]

Sheth VM, Pandya AG