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All samples were dispatched to MetaMetrics Laboratory in frozen condition (20 C) every two weeks and stored for no more than 1.5 months before analysis

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Acknowledgments The authors would like to thank the biological Science Department of Peking ChipStone for helpful on the figure conduction related to this work Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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