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activation of cytochrome c and the apoptotic machinery
PAHs are known to induce severe redox stress in cells and tissues, leading to the oxidation of nucleic acids, proteins, and lipids ( As expected, testis samples from exposed animals showed activation of DNA repair machinery, including the 8-oxoguanine glycosylase (OGG1), a base excision repair enzyme responsible for the recognition and removal of 8-OHdG, histone H2A variant, H2AX and PARP-1
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