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High homocysteine levels are problematic because they have been linked to heart disease and atherosclerosis.32 In people who are deficient or have mutations in the enzymes that catalyze the production of glutathione from homocysteine, the methylation cycle will be under pressure to remove excess homocysteine

Impaired ATP production and defects in ETC could be associated with increased mitochondrial production of superoxide and hydrogen peroxide radicals creating adaptive and synergistic damage

Also, unlike therapies that are used to treat blood pressure or cholesterol, the perception that these are not chronic disease therapies may also be contributing

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Innovative Food Science and Emerging Technologies, 68, 102642

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