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It was found that PLC-1-PI3K-AKT signal axis was very important for CCA development and EMT, and AKT can be used as a therapeutic target to overcome the chemotherapy resistance of CCA patients with high PLC-1 expression, thus inhibiting the growth of tumor and obviously improving the postoperative survival of patients ( The pathogenesis of myelodysplastic syndrome (MDS) and erythropoiesis involve PLC-1/protein kinase C (PKC) signal transduction, especially nuclear PLC-1 gene ( Figure 5 ) ( Figure 5 The expression level of phosphoinositide-specific phospholipase C1(PI-PLC1) in MDS was lower than that in normal tissue

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6c), Salviolone group ( P = 0.0092

25 , 321335 (2000) Koole, C