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We next further investigated whether the observed bell-shaped profile induced by high concentrations of dimeric macrocycles (3,000 nM) or HGF (30 nM) might be due to off-target inhibition of constitutively activated RTKs, which could potentially transactivate Met phosphorylation

BPC-157 also works by inhibiting 4-hydroxynonenal, a compound that slows tissue growth and healing

However, in cells co-expressing CTR and RAMP3, similar potency was observed for the analogues (Supplementary Fig

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Material and methods Animals The GCLC floxed mice were introduced from The European Mouse Mutant Archive (EMMA)