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and the potential for unmeasured confounding factors such as reasons underlying the decision to initiate GLP-1 RA therapy that could have influenced RA outcomes, they wrote
Landwehr, L
Butyrate is used by colonocytes to generate energy, stabilizes hypoxia-inducible factor to maintain the anaerobic environment in the gut, maintains gut barrier integrity by regulating Claudin-1 and synaptopodin expression, limits pro-inflammatory cytokines (IL-6, IL-12), and inhibits oncogenic pathways (Akt/ERK, Wnt, and TGF- signaling)
These medications act by mimicking GLP-1, causing increased feelings of fullness and reduced appetite, leading to weight loss for some people
It worked in most, but given the weekly commitment with short term results, it was impractical for most
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