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The exception is a subset of less than 20% of lethal CaPs in which sequential potent ADT induces AR-independence, which are often referred to as neuroendocrine CaP (NEPC) [28, 29]

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Because these therapies are not in widespread use as ESA adjuvants, they are presented here primarily for general information, but were not considered by the Anemia Work Group for inclusion in Guidelines or CPRs addressing ESA adjuvants

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