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Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial

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This approach of targeting the entire MC4R pathway , rather than the MC4R gene alone, enables a more viable commercial model by consolidating multiple ultra-rare diseases into a single development program