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They are the most common pelvic tumours in women of reproductive age, affecting up to 70-80% of women by age 50, though many remain asymptomatic. When fibroids do cause symptoms, they can significantly impair quality of life and sometimes affect fertility

Emanuele S, Lauricella M, DAnneo A, Carlisi D, De Blasio A, Di Liberto D, et al

(2016) Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia, Oncotarget , 7 , 14659-14672, doi: Njlsson, R., and Norgren, S