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Mechanistically, the role of KHK in alcohol preference is most likely due to the role of fructose metabolism in the activity levels of aldehyde dehydrogenase (ALDH), the mitochondrial enzyme that metabolizes the toxic intermediate in ethanol metabolism, acetaldehyde

And, certainly, continue the traditional therapies

The enzymatic activity of ALDH2 was significantly decreased in the liver of Aldh2*2 KI homozygous and heterozygous mice compared with that of WT mice, which is relevant to human ALDH2*2 carriers (Fig

Additional factors, such as cohort differences, dietary habits, and timing of food intake, may also contribute, as the studies are based on spot urine samples

Ann N Y Acad Sci 1033, 3041

Cagri-