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In deeply anaesthetised rats (placed in ventral position) the tail was transected with a surgical scalpel 3 cm from the tip (and submerged into a tube with 15 ml of saline at room temperature in vertical position) and the duration and amount of bleeding were measured to evaluate the hemostatic effect of the agents or saline administration

Exposure to hypobaric hypoxic conditions at elevated altitudes results in redox imbalance characterized by increased ROS production and concomitant impairment of endogenous antioxidant defenses 31

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The results have been consistent across dozens of high-quality rat studies that researchers got very excited

SabourianPFrounchiMKianiSMashayekhanSKheirabadiMZHeydariYet alTargeting reactive astrocytes by pH-responsive ligand-bonded polymeric nanoparticles in spinal cord injury

10.1016/j.freeradbiomed.2019.08.033 93