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Nat Rev Dis Primers (2015) 1:15017

It also carries real risks: it depletes good minerals like zinc and magnesium, stresses the kidneys, and mobilizes metals out of storage in a way that can make people feel worse if their excretion pathways aren't ready

Always consult a healthcare provider before starting or stopping any medication while on Isotretinoin

Unapproved New Drug: Any substance that has not completed the formal FDA approval process and fails to qualify for a strict 503A or 503B exemption is classified as an unapproved new drug, the distribution of which is prohibited in interstate commerce

& Herrera, M.D