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Subsequently, the effects of these drugs on glioma metabolism, proliferation, and apoptosis were explored in vitro and in vivo, using drug concentrations significantly lower than their respective IC50 values

Long-term Use and Zinc Some evidence suggests that long-term, high-dose glutathione use may lower zinc levels in the body

An enzyme called glutathione peroxidase 4 (GPX4) uses glutathione to neutralize the lipid peroxides that cause ferroptosis

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Age plays a modest role, with older adults sometimes experiencing slightly slower clearance, though age alone is not a strong determinant