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Management of associated conditions is essential: Diabetes control : Pioglitazone and GLP-1 receptor agonists (such as liraglutide or semaglutide) show hepatic benefits in clinical trials, but their use for NASH is off-label in the UK and should be initiated and monitored by specialists after careful riskbenefit discussion

This randomised controlled trial compared tirzepatide at three doses directly against semaglutide 1 mg in 1,879 adults with type 2 diabetes over 40 weeks

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Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis

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