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The authors ackowledge support by the bwHPC initiative (high-performance computing in Baden-Wuerttemberg, Germany)

4) (Case, 2017

Observational studies have tracked the effects of caloric restriction on lean, healthy individuals, and demonstrated that moderate restriction (2230% decreases in caloric intake from normal levels) improves heart function and reduces markers of inflammation (C-reactive protein, tumor necrosis factor [TNF]), risk factors for cardiovascular disease (LDL cholesterol, triglycerides, blood pressure), and diabetes risk factors (fasting blood glucose, insulin levels)

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However, injectable semaglutide may be more convenient for patients who wish to administer a weekly injection rather than keep up with a daily dose of medication

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