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It should again be noted that mitochondria do not have the enzymes required for GSH synthesis and must import GSH from the cytoplasm [46]

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Consequently, an extracellular cystine or intracellular cysteine deficiency or inhibition of system ( SLC7A11 ) would reduce the GSH level, inhibit GSH-dependent GPX4 activity, and lead to the intracellular accumulation of L-ROS and cell death (Dolma et al., 2003

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