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Patients receiving warfarin should undergo more frequent monitoring when initiating or adjusting semaglutide therapy, with warfarin dose adjustments made as necessary to maintain therapeutic anticoagulation
This occurs partly due to delayed gastric emptying and partly through central nervous system effects, as GLP-1 receptors in the brainstem influence nausea and satiety signals
The magnitude of weight loss varies by product: semaglutide 2.4mg (Wegovy) can achieve approximately 15% reduction in body weight, while liraglutide 3mg (Saxenda) typically produces around 8% weight loss
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We prioritized evidence derived from human clinical trials, placing a distinct emphasis on randomized controlled trials (RCTs) and comprehensive systematic reviews published from 2015 onwards, reflecting the most recent and rigorous advancements in the field
