The most common side effects of tirzepatide include nausea, constipation, diarrhea, and fatigue, especially during the first few weeks as your body adjusts

Contact your healthcare provider if you experience: Absent periods (amenorrhea): Missing three or more consecutive menstrual cycles if previously regular, or six or more months if previously irregular Heavy bleeding (menorrhagia): Soaking through a pad or tampon every hour for several consecutive hours, or periods lasting longer than seven days Severe pain: New or worsening menstrual cramping not relieved by over-the-counter medications Intermenstrual bleeding: Bleeding or spotting between periods that persists beyond initial treatment months Pregnancy possibility: Any missed period when pregnancy is possible, as tirzepatide is not recommended during pregnancy Urgent warning signs: Heavy bleeding with dizziness, fainting, rapid heartbeat, or severe weakness requires emergency evaluation Your healthcare provider may recommend specific investigations to evaluate persistent menstrual irregularities
The caveat is an open bottle is only good for 28 days after opening
Frequently Asked Questions 1
For others, especially during the first week at a new dose, the nausea can be intense enough to limit activities or require rest
This variability is not just a theoretical concern