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Because the liver is responsible for processing such a high volume of compounds, it requires a massive "cleanup crew" to prevent those compounds from damaging the liver's own tissues

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Key challenges include post-translational modifications (PTMs), isomer differentiation, and fragmentation complexity

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(2024) showed that GHRP-6 prevented doxorubicin-induced myocardial and extra-myocardial damage in rats by attenuating pro-oxidant activity, enhancing antioxidant reserves, protecting mitochondrial ultrastructure, and upregulating the anti-apoptotic gene Bcl-2