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Supplements containing L-carnitine are usually given to people whose natural L-carnitine levels are low
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In the current study, the dose range was 23 g/day and there was no significant dose-dependence from l-carnitine efficacy on BMI in T2DM patients, so the lower dose of 2 g/day was selected as recommended dose
Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]
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