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Individual factors such as baseline gut sensitivity, concurrent medications (especially metformin, which can independently cause diarrhea), and pre-existing conditions like irritable bowel syndrome significantly influence whether diarrhea develops and its severity

They don't account for secondary bacterial factors

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Arnon, T

[9] Dosing and Response Assessment Mechanisms of Action Anti-obesity medications operate through one or more of the following mechanisms: Suppression of appetite or enhancement of satiety through central nervous system pathways

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