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Christenson LJ, Borrowman TA, Vachon CM, et al

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The biosynthesis of S-GAGs begins in the cytoplasm with the formation of a tetrasaccharide linkage to the core proteins, catalyzed by the sequential actions of four glycosyltransferases, which adds one xylose, two galactose, and one glucuronic acid residues (Xyl-gal-gal-glucA)