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They also presented data suggesting the presence of putative synaptic markers in GLP-1 and enterochromaffin cells 39,58,59 , as well as viral tracing indicating synaptic-like connections with a small number of vagal afferents 38,59

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By studying the animals in metabolic cages that measure metabolic rate, it was further explored that, despite the GLP-1-MK-801-treated mice being significantly smaller in size and consuming less food than the obese control group, they burned the same amount of calories