HEK293 cells were transiently transfected with GLP-1 receptor and cyclic-AMP sensor using YFP-Epac-RLuc (CAMYEL)
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Michaelsen M, Drasbek KR, Valentin JB, et al
The ultimate pathways whereby these molecular changes may translate into changes in body weight and metabolic (dys)function are yet to be fully disclosed, but alterations in the hypothalamic proteome involved in inflammatory and apoptotic processes, as well as in autophagy and vesicular trafficking, may play a role
It is considered one of the most versatile peptides for systemic and local regeneration