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Muscle preservation during weight loss depends primarily on protein intake (typically 1.2 to 1.6 grams per kilogram body weight), resistance training, and the rate of weight loss

Semaglutide is a GLP-1 receptor agonist analog

It's generally appropriate for adults with a BMI of 30 or higher, or 27 or higher alongside a condition like high blood pressure, high cholesterol, or type 2 diabetes

This means Retatrutide does not rely solely on reducing food intake

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Typically administered weekly, they can be given intramuscularly or subcutaneously