Antioxidant supplements, which include vitamins C and E, high-dose selenium, and polyphenols, may also interfere with chemotherapys ROS-mediated cytotoxicity (204)
Hyer, MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo
Disorders of Cobalamin (Vitamin B12) Metabolism: Emerging Concepts in Pathophysiology, Diagnosis and Treatment
The chloroplastic isoform is likely required for the de novo methionine synthesis whereas cytosolic isoforms are most probably involved in the regeneration of Met from homocysteine (Ravanel et al., 2004)
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Large-scale human trials evaluating lifespan, disease prevention, or long-term aging outcomes do not currently exist